By Lennart Philipson (auth.), Professor Dr. Walter Doerfler (eds.)

A confusing epidemiological challenge used to be the motive force in the back of the invention of human adenoviruses through Wallace Rowe and his colleagues 30 years in the past. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the brink of quantitative virology, and within the comparable 12 months the double-helical constitution of DNA used to be chanced on and have become a cornerstone of mo­ lecular biology. the possibility of adenoviruses as examine instruments within the molecular and mobile biology of eukaryotic cells was once well-known as early because the past due Fifties and early Sixties via numerous investigators. Structural and biochemical stu­ dies ruled the early years. In 1962, many of the adenoviruses have been the 1st human viruses proven to be oncogenic in experimental animals. hence adenovirology provided the investigator the complete gamut of host cellphone interactions, effective and abortive, in addition to trans­ shaped and tumor cellphone structures. the chances that adenoviruses afforded for the examine of the molecular biology and genetics of eukaryotic cells have been absolutely rea­ lized within the overdue Nineteen Sixties and the 1970s.

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