By H. Stein (auth.), Priv.-Doz. Dr. Wolf-Dieter Ludwig, Prof. Dr. Eckhard Thiel (eds.)

The improvement of latest options resembling immuno­ phenotyping, cytogenetic investigations and, extra lately, molecular experiences has significantly elevated our diagnostic repertoire and broadened our rules in regards to the biology of acute leukemias. whereas immunophenotyping with mono­ clonal antibodies has yielded elevated diagnostic precision and made it attainable to boost a hugely reproducible category of acute leukemias in accordance with cell-biological positive factors, additional insights were won into the patho­ genetic mechanisms occupied with leukemogenesis by way of cytogenetic detection of obtained structural chromosomal abnormalities. research of the leukemia-associated chromo­ somal breakpoints utilizing molecular thoughts can now pinpoint many genomic websites crucial for regular boost­ ment and maturation of hematopoietic cells yet functionally disrupted in leukemic cells. the most objective of the foreign workshop that we held in Berlin with a pick out crew of scientists and clinicians keen on leukemia learn used to be to explain the state-of-the-art and new advancements within the immunologic, cytogenetic, and molecular characterization of acute leukemias and to debate the scientific significance of mobile­ organic positive factors. After introductory survey lectures facing the immunological and molecular-biological features of standard vs. malignant lymphatic and myeloid progenitor cells, the workshop established on con­ tributions characterizing the immunophenotype and either numerical and structural chromosomal abnormalities in acute leukemias.

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