By H. Stein (auth.), Priv.-Doz. Dr. Wolf-Dieter Ludwig, Prof. Dr. Eckhard Thiel (eds.)
The improvement of latest options resembling immuno phenotyping, cytogenetic investigations and, extra lately, molecular experiences has significantly elevated our diagnostic repertoire and broadened our rules in regards to the biology of acute leukemias. whereas immunophenotyping with mono clonal antibodies has yielded elevated diagnostic precision and made it attainable to boost a hugely reproducible category of acute leukemias in accordance with cell-biological positive factors, additional insights were won into the patho genetic mechanisms occupied with leukemogenesis by way of cytogenetic detection of obtained structural chromosomal abnormalities. research of the leukemia-associated chromo somal breakpoints utilizing molecular thoughts can now pinpoint many genomic websites crucial for regular boost ment and maturation of hematopoietic cells yet functionally disrupted in leukemic cells. the most objective of the foreign workshop that we held in Berlin with a pick out crew of scientists and clinicians keen on leukemia learn used to be to explain the state-of-the-art and new advancements within the immunologic, cytogenetic, and molecular characterization of acute leukemias and to debate the scientific significance of mobile organic positive factors. After introductory survey lectures facing the immunological and molecular-biological features of standard vs. malignant lymphatic and myeloid progenitor cells, the workshop established on con tributions characterizing the immunophenotype and either numerical and structural chromosomal abnormalities in acute leukemias.
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