By Arthur Weissbach (auth.), Dr. Jean-Pierre Jost, Dr. Hans-Peter Saluz (eds.)

The prevalence of 5-methylcytosine in DNA used to be first defined in 1948 through Hotchkiss (see first chapter). popularity of its attainable physiologi­ cal position in eucaryotes used to be first recommended in 1964 via Srinivasan and Borek (see first chapter). in view that then paintings in a good many laboratories has proven either the ubiquity of 5-methylcytosine and the catholicity of its attainable regulatory functionality. The explosive raise within the variety of courses facing DNA methylation attests to its significance and makes it very unlikely to write down a finished assurance of the literature in the scope of a normal assessment. because the book of the three latest books facing the topic (DNA methylation via Razin A. , Cedar H. and Riggs A. D. , 1984 Springer Verlag; Molecular Biology of DNA methylation by way of Adams R. L. P. and Burdon R. H. , 1985 Springer Verlag; Nucleic Acids Methylation, UCLA Symposium suppl. 128, 1989) enormous growth either within the ideas and effects has been made within the box of DNA methylation. hence we requested a number of authors to put in writing chapters facing features of DNA methyla­ tion during which they're specialists. This e-book can be most beneficial for college students, academics in addition to researchers within the box of differentiation and gene legislation. we're such a lot thankful to all our colleagues who have been keen to spend a lot effort and time at the book of this e-book. We additionally are looking to exhibit our gratitude to Yan Chim Jost for her assist in getting ready this book.

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